Achieved | Achievement | % of players | Unlock date |
|---|---|---|---|
 | One-Eyed Freak Defeat the Cycloid | 97.06% | |
 | Drawrings Doodle something on the whiteboard in SP | 94.65% | |
 | Flagon of Chuckles Drink a beer in SP | 87.53% | |
 | Extermination Kill 50 aliens | 83.8% | |
 | Juiced Take steroids in SP | 80.51% | |
 | Nobody Likes a Whiner Knock out the talent at the talk show | 77.43% | |
 | Annihilation Kill 100 aliens | 69.04% | |
 | Natural Disaster 3x Kill 3 aliens at once | 63.91% | |
 | Pit Champion Defeat the Battlelord in Las Vegas | 56.52% | |
 | Nuclear Devastation Kill 250 aliens | 52.2% | |
 | Big Guns, Big Ships Blow up 5 enemy gunships or dropships | 51.88% | |
 | Baron von Nukem Shoot down 20 alien fighters | 47.65% | |
 | Not Bad for a Human Defeat the Alien Queen | 42.25% | |
 | Dead Useful Kill 10 aliens with environmental explosives | 41.61% | |
 | On the Noggin' Kill 30 aliens with headshots | 41.3% | |
 | Turd Burglar Find and steal a piece of poo | 39.05% | |
 | Road Rage Kill 15 aliens with the monster truck | 37.36% | |
 | Full Body Tourettes Get knocked down 10 times | 36.28% | |
 | He's Got a Hologram! Use a Holoduke in SP | 35.53% | |
 | A Good Dam Fight Defeat the Battlelord on the Hoover Dam | 33.67% | |
 | I Need a Towel Get hit by 10 Pregnator bombs | 33% | |
 | Octacide Defeat the Octaking | 29.5% | |
 | Beating the One-Eyed Worm Defeat the Energy Leech | 26.09% | |
 | Piece of Cake Complete the SP campaign on Easy Difficulty | 25.76% | |
 | Noms Eat 10 pieces of food during the SP campaign | 25.14% | |
 | Fork the Pork Kill 6 aliens with the forklift | 24.07% | |
 | Lots of Whacking Win a game of Alien Abortion in the strip club | 22.15% | |
 | Sticky Bomb Like You! Put a Trip Mine on a live alien | 22.11% | |
 | Hippy-Stomper Foot stomp 12 aliens | 21.97% | |
 | Substance Abuser Drink beer while on steroids or vice-versa in SP | 21.74% | |
 | Judge, Jury, Executioner Execute 20 aliens | 21.45% | |
 | Sunday, Black Sunday Shoot down the blimp above the stadium | 19.93% | |
| Let's Rock Complete the SP campaign on Normal Difficulty | 17.73% | |
 | Duke Angry, Duke Smash! Kill 15 aliens with melee attacks while on steroids | 16.63% | |
 | Tosser... in the Literal Sense Kill 10 aliens with tossed objects | 11.39% | |
 | Special Thanks Watch the credits all the way through | 11.07% | |
 | I Need a Date Look at every page of a calendar in SP | 10.13% | |
 | Trapper Kill 10 aliens with Trip Mines | 9.07% | |
 | Freeze Well! Kill 15 frozen aliens | 7.89% | |
 | Air-Duke Win air hockey with a score of 7-0 in the strip club | 7.02% | |
 | Heart to Heart Finish Doctor Proton | 4.14% | |
 | Party Animal Drink all of the beers in the strip club | 3.88% | |
 | Bloody Red Rover Kill 30 enemies with the moon rover | 3.57% | |
 | Gunslinger Carry the gold pistol through the whole SP campaign | 3.52% | |
 | Hedonist, not Misogynist Discover and reject the video game that lets you slap women | 3.5% | |
 | Another Piece of Cake Beat the DLC campaign on Easy Difficulty | 3.47% | |
| Come Get Some Complete the SP campaign on Hard Difficulty | 3.43% | |
 | Threesome Kill 3 enemies within 3 seconds with the Impregnader | 3.3% | |
 | Companion Barrel Unlock the secret closet at the end of the Forkstop | 2.78% | |
| Let's Rock Out Beat the DLC campaign on Normal Difficulty | 2.76% | |
 | Balls of Steel Earn a 1,000,000 pinball score in SP | 2.31% | |
 | Passive Aggressive Let 20 enemies die by someone else's hand | 2.1% | |
 | I Am All That Is Man Discover all ego cap rewards | 2.03% | |
 | Bucket Head Find all 3 helmets in the SP campaign | 2.02% | |
 | Pescaphobe Kill all of the catfish in the underwater level | 1.61% | |
 | Call Waiting Listen to all phone messages | 1.58% | |
 | Damn, I'm Good Complete the SP campaign on Insane Difficulty | 1.33% | |
| Come Get a Little More Beat the DLC campaign on Hard Difficulty | 1.28% | |
 | Bubble Buster Kill 10 expanded enemies with melee attacks | 1.1% | |
 | I Am All That Is Man - Again! Discover all Ego cap rewards in the DLC campaign | 1.07% | |
 | Scientits Earn a 1,000,000 pinball score on the Scientits pinball machine | 1.06% | |
 | Damn, I'm REALLY Good Beat the DLC campaign on Expert Difficulty | 0.89% |